By reading this book, you will develop the skills to perceive a space and its contents in light, and be able to devise a layout of luminaires that will provide that lit appearance.
Written by renowned lighting expert Christopher (Kit) Cuttle, the book:
Practical lighting design involves devising three-dimensional light fields that create luminous hierarchies related to the visual significance of each element within a scene. By providing you with everything you need to develop a design concept - from the understanding of how lighting influences human perceptions of surroundings, through to engineering efficient and effective lighting solutions - Kit Cuttle instills in his readers a new-found confidence in lighting design.
Every believer needs help to develop a relationship with the God of Heaven. One-on-one discipleship provides believers with the needed atmosphere of love, care, and patience, as they are personally mentored by more mature believers in the scriptures. These lessons are meant to help believers of all maturity levels grow in the faith, so that they can stand against Satan's attacks and live victoriously for Jesus Christ (Matthew 5:13-16). This book is the second in a series of six, which covers how to delight in God's Word. It is divided into five lessons, which are as follows: 1. The Sufficiency of Scripture 2. The Preservation of God's Word 3. Faith Comes by Hearing 4. Responding to the Word of God 5. How to Take Notes Each lesson comes with a set of objectives, interactive questions and answers, and additional homework to help the student study through the scriptures at a structured pace.
In this book we first review the ideas of Lie groupoid and Lie algebroid, and the associated concepts of connection. We next consider Lie groupoids of fibre morphisms of a fibre bundle, and the connections on such groupoids together with their symmetries. We also see how the infinitesimal approach, using Lie algebroids rather than Lie groupoids, and in particular using Lie algebroids of vector fields along the projection of the fibre bundle, may be of benefit.
Of the two major products of the gene (proteins and microRNAs) it is the protein that is the functional unit of biology. A combinatorial association of 20 amino acids in linear chains of up to 30,000 residues generates, or can generate in theory, many more proteins than there are stars in our universe. The protein molecule can be chemically active, in the form of an enzyme, whose catalytic effect can speed up chemical reactions by a thousand- to a million-fold. It can be a structural component acting as a tissue support or allowing the transmission of force. It can function as a binding protein, acting to transport other molecules or atoms or act as a receptor binding its ligand to transmit information into the cell.Â
Not stated in the central dogma, but generally taken for granted, was that each protein product of the gene had one single biological function. This one-protein-one-function hypothesis was falsified by the first example of a protein exhibiting two functions. In addition, the transparency of a protein is not really a functional property but is a physical property of these molecules. So it was not until the 1990s that additional examples of proteins exhibiting more than one function were identified and another term to describe this phenomenon was introduced. Connie Jeffery, from the University of Chicago, introduced the term Protein Moonlighting in 1999 for the phenomenon of proteins having more than one unique biological function. Since the introduction of the term, protein moonlighting, a slow trickle of serendipitous discoveries of moonlighting proteins has been made such that at the time of writing over one hundred examples of such proteins have been made.Â While this is a small number of examples, it is possibly only the tip of the iceberg that is the proportion of moonlighting proteins in biology.
Protein moonlighting has only come to prominence in the last 15 years. Although only a small number of protein families have been found to moonlight, the consequences of such additional activities are alreadyÂ known to be of significance in both biological and pathological/medical terms. Moonlighting proteins are known to be involved in human diseases such as cancer and there is rapidly emerging evidence for a major role for protein moonlighting in the infectious diseases. Protein moonlighting has potential consequences for various branches of biology.Â The most obvious is the field of protein evolution. In moonlighting proteins not one, but two or more, active sites have evolved. This calls into question our current models of protein evolution and generates a range of questions as to the evolutionary mechanisms involved. Further, as it is emerging that moonlighting protein homologues do not necessarily share particular moonlighting activities the level of evolutionary complexity in generating biologically active sites seems much greater than was previously thought.Â
This book brings together a biochemist (Henderson) an evolutionary biologist (Fares) and a protein bioinformaticist (Martin) who have had a long-term interest in protein moonlighting. The discussion covers all aspects of the phenomenon of protein moonlighting from its evolution to structural biology and on the the biological and medical consequences of its occurrence. The book should be of interest to the widest range of biomedical scientists.